Gene
hmx3a
- ID
- ZDB-GENE-001020-1
- Name
- H6 family homeobox 3a
- Symbol
- hmx3a Nomenclature History
- Previous Names
-
- hmx3
- Nkx5-1
- nkx5.1
- zgc:109845
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have sequence-specific DNA binding activity. Involved in inner ear morphogenesis and posterior lateral line development. Predicted to localize to nucleus. Is expressed in dorsolateral placode; nervous system; neural rod; neural tube; and otic vesicle. Orthologous to human HMX3 (H6 family homeobox 3).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 44 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:109845 (16 images)
- eu350 (16 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
CRISPR1-hmx3a | (3) | |
CRISPR2-hmx3a | (4) | |
CRISPR3-hmx3a | (4) | |
MO1-hmx3a | N/A | Feng et al., 2010 |
MO2-hmx3a | N/A | Feng et al., 2010 |
MO3-hmx3a | N/A | (2) |
MO4-hmx3a | N/A | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | HMX Homeobox Transcription Factors | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
---|---|---|---|---|---|---|
UniProtKB:Q504H8
|
297 | |||||
UniProtKB:F1QMB1
|
297 | |||||
UniProtKB:A0A8M2B544
|
296 |
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Interactions and Pathways
No data available
Plasmids
No data available
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(hsp70l:hmx3a) |
|
| 1 | Hartwell et al., 2019 |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-208G24 | ZFIN Curated Data | |
Encodes | EST | eu350 | Thisse et al., 2005 | |
Encodes | cDNA | MGC:109845 | ZFIN Curated Data | |
Encodes | cDNA | MGC:191416 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131634 (1) | 2058 nt | ||
Genomic | GenBank:AL773596 (2) | 206778 nt | ||
Polypeptide | UniProtKB:F1QMB1 (1) | 297 aa |
- Olson, H.M., Maxfield, A., Calistri, N.L., Heiser, L.M., Qian, W., Knaut, H., Nechiporuk, A.V. (2024) RhoA GEF Mcf2lb regulates rosette integrity during collective cell migration. Development (Cambridge, England). 151(1):
- England, S.J., Rusnock, A.K., Mujcic, A., Kowalchuk, A., de Jager, S., Hilinski, W.C., Juárez-Morales, J.L., Smith, M.E., Grieb, G., Banerjee, S., Lewis, K.E. (2023) Molecular analyses of zebrafish V0v spinal interneurons and identification of transcriptional regulators downstream of Evx1 and Evx2 in these cells. Neural Development. 18:88
- Haws, W., England, S., Grieb, G., Susana, G., Hernandez, S., Mirer, H., Lewis, K. (2023) Analyses of binding partners and functional domains for the developmentally essential protein Hmx3a/HMX3. Scientific Reports. 13:11511151
- Shi, T., Beaulieu, M.O., Saunders, L.M., Fabian, P., Trapnell, C., Segil, N., Crump, J.G., Raible, D.W. (2023) Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes. eLIFE. 12:
- Tan, A.L., Mohanty, S., Guo, J., Lekven, A.C., Riley, B.B. (2022) Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear. Developmental Biology. 492:139-153
- England, S.J., Cerda, G.A., Kowalchuk, A., Sorice, T., Grieb, G., Lewis, K.E. (2020) Hmx3a Has Essential Functions in Zebrafish Spinal Cord, Ear and Lateral Line Development. Genetics. 216(4):1153-1185
- Hartwell, R.D., England, S.J., Monk, N.A.M., van Hateren, N.J., Baxendale, S., Marzo, M., Lewis, K.E., Whitfield, T.T. (2019) Anteroposterior patterning of the zebrafish ear through Fgf- and Hh-dependent regulation of hmx3a expression. PLoS Genetics. 15:e1008051
- Gou, Y., Vemaraju, S., Sweet, E.M., Kwon, H.J., Riley, B.B. (2018) sox2 and sox3 play unique roles in development of hair cells and neurons in the zebrafish inner ear. Developmental Biology. 435(1):73-83
- Guerra, A., Germano, R.F., Stone, O., Arnaout, R., Guenther, S., Ahuja, S., Uribe, V., Vanhollebeke, B., Stainier, D.Y., Reischauer, S. (2018) Distinct myocardial lineages break atrial symmetry during cardiogenesis in zebrafish. eLIFE. 7
- Nikaido, M., Acedo, J.N., Hatta, K., Piotrowski, T. (2017) Retinoic acid is required and Fgf, Wnt, and Bmp signaling inhibit posterior lateral line placode induction in zebrafish. Developmental Biology. 431(2):215-225
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