ZFIN ID: ZDB-GENE-000816-1
Gene Name: fibroblast growth factor receptor 3
Gene Symbol: fgfr3
Previous Names: Z-FGFR3, fc27h01, sb:eu563, wu:fc27h01 (1)
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 32 figures from 22 publications
Directly Submitted Expression Data: 6 figures (17 images) from Thisse et al., 2005 [eu563]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  anatomical structure, basal plate midbrain region, brain, caudal vein plexus (all 44) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010237Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018391Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1675 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10458 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa13480 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15832 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa35442 Point Mutation Unknown Unknown ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH fgfr3 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    achondroplasia Achondroplasia 100800
    cervix carcinoma Cervical cancer, somatic 603956
    colon carcinoma Colorectal cancer, somatic 114500
    colorectal cancer Colorectal cancer, somatic 114500
    LADD syndrome LADD syndrome 149730
    seminoma Spermatocytic seminoma, somatic 273300
    testicular cancer Spermatocytic seminoma, somatic 273300
    testicular germ cell cancer Spermatocytic seminoma, somatic 273300
    thanatophoric dysplasia Thanatophoric dysplasia, type I 187600
    Thanatophoric dysplasia, type II 187601
    urinary bladder cancer Bladder cancer, somatic 109800
    CATSHL syndrome 610474
    SADDAN 616482
    Hypochondroplasia 146000
    Crouzon syndrome with acanthosis nigricans 612247
    Muenke syndrome 602849
    Nevus, epidermal, somatic 162900
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process apoptotic process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR016248 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR028174 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA fgfr3-002 (1) 3233
    ottdart00000047671 (1) 2999
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM fgfr3 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    fgfr3Contained in: [BAC] CH73-92M9 (1) (order this), CH211-195N12 (1) (order this), DKEY-181A13 (1) (order this)
    fgfr3Encodes: [EST] eu563 (1), fc27h01
    [cDNA] MGC:193660 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131606 (1) 8112bp
    Genomic GenBank:CR556722 (1) 205873bp Blast at MegaBLAST
    Polypeptide UniProtKB:X1WBA9 (1) 821aa
    Sequence Clusters UniGene:10434 (1)
    Sequence Information (all 44)
    OTHER fgfr3 GENE PAGES
  • Gene:58129 (1)
  • VEGA:OTTDARG00000037669 (1)
  • Ensembl(GRCz10):ENSDARG00000004782 (1)
  • ORTHOLOGY for fgfr3 (Chr: 13)
    Species Symbol Chromosome Accession # Evidence
    Human FGFR3 4
  • Gene:2261
  • OMIM:134934
  • HGNC:3690
  • Amino acid sequence comparison (5)
    Conserved genome location (synteny) (2)
    Mouse Fgfr3 5
  • MGI:95524
  • Gene:14184
  • Amino acid sequence comparison (4)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (65)