Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-000816-1
Gene Name: fibroblast growth factor receptor 3
Gene Symbol: fgfr3
Previous Names: Z-FGFR3, fc27h01, wu:fc27h01 (1)
Location: Chr: 13   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 19 figures from 14 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  diencephalon, dorsal telencephalon, hindbrain, hypothalamus (all 11) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 1 genotype
Alleles: la010237Tg, la018391Tg, sa10458, sa13480, sa15832 (all 6) expand
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Achondroplasia 100800
Bladder cancer, somatic 109800
CATSHL syndrome 610474
Cervical cancer, somatic 603956
Colorectal cancer, somatic 114500
Crouzon syndrome with acanthosis nigricans 612247
Hypochondroplasia 146000
LADD syndrome 149730
Muenke syndrome 602849
Nevus, epidermal, somatic 162900
Spermatocytic seminoma, somatic 273300
Thanatophoric dysplasia, type I 187600
Thanatophoric dysplasia, type II 187601
GENE ONTOLOGY
Ontology GO Term
Biological Process apoptotic process (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 18)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR016248 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR028176 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA fgfr3-001 (1) 1162
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM fgfr3 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    fgfr3 Contained in: [BAC] CH73-92M9 (1) (order this), CH211-195N12 (1) (order this), DKEY-181A13 (1)
    fgfr3 Encodes: [EST] fc27h01
    [cDNA] MGC:193660 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131606 (1) 3002 bp
    Genomic GenBank:CR556722 (1) 205873 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QPA0 (1) 804 aa
    Sequence Clusters UniGene:10434 (1)
    Sequence Information (all 30)
    OTHER fgfr3 GENE PAGES
  • Gene:58129 (1)
  • Ensembl(Zv9):ENSDARG00000004782 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish fgfr3 13  
    Human FGFR3 4 (4p16.3)
  • OMIM:134934
  • Gene:2261
  • Mouse Fgfr3 5 ( 17.83 cM)
  • MGI:95524
  • Gene:14184
  • Orthology Details
    CITATIONS (55)