ZFIN ID: ZDB-GENE-000816-1
Gene Name: fibroblast growth factor receptor 3
Gene Symbol: fgfr3
Previous Names: Z-FGFR3, fc27h01, wu:fc27h01 (1)
Location: Chr: 13   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 25 figures from 20 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  brain, caudal vein plexus, diencephalon, diencephalon dorsal region (all 31) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: fgfr3sa1675/sa1675(Tupfel long fin)

Allele Type Mutagen Suppliers
la010237Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018391Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1675 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10458 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa13480 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15832 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Phenotype of Human Orthologue OMIM Phenotype ID
    Achondroplasia 100800
    Bladder cancer, somatic 109800
    CATSHL syndrome 610474
    Cervical cancer, somatic 603956
    Colorectal cancer, somatic 114500
    Crouzon syndrome with acanthosis nigricans 612247
    Hypochondroplasia 146000
    LADD syndrome 149730
    Muenke syndrome 602849
    Nevus, epidermal, somatic 162900
    Spermatocytic seminoma, somatic 273300
    Thanatophoric dysplasia, type I 187600
    Thanatophoric dysplasia, type II 187601
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process apoptotic process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR003598 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR016248 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR028176 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50835 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA fgfr3-002 (1) 3233
    ottdart00000047671 (1) 2999
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fgfr3 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    fgfr3 Contained in: [BAC] CH73-92M9 (1) (order this), CH211-195N12 (1) (order this), DKEY-181A13 (1) (order this)
    fgfr3 Encodes: [EST] fc27h01
    [cDNA] MGC:193660 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131606 (1) 3002 bp
    Genomic GenBank:CR556722 (1) 205873 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QPA0 (1) 804 aa
    Sequence Clusters UniGene:10434 (1)
    Sequence Information (all 48)
    OTHER fgfr3 GENE PAGES
  • Gene:58129 (1)
  • VEGA:OTTDARG00000037669 (1)
  • Ensembl(Zv9):ENSDARG00000004782 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish fgfr3 13  
    Human FGFR3 4 (4p16.3)
  • OMIM:134934
  • Gene:2261
  • Mouse Fgfr3 5 ( 17.83 cM)
  • MGI:95524
  • Gene:14184
  • Orthology Details
    CITATIONS (60)