Gene

adgrl2a

ID

ZDB-GENE-000607-49

Name

adhesion G protein-coupled receptor L2a

Symbol

adgrl2a Nomenclature History

Previous Names

lphn2
lphn2a
id:ibd2808
lphn2.1 (1)
wu:fb72a08

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and brain development. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and cell surface receptor signaling pathway. Predicted to be located in axon and membrane. Predicted to be active in neuron projection and plasma membrane. Is expressed in brain; eye; and tail bud. Orthologous to human ADGRL2 (adhesion G protein-coupled receptor L2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Camillo et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adgrl2a Human Ortholog

No data available

Associated With adgrl2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000203	GPS motif
Conserved_site	IPR017983	GPCR, family 2, secretin-like, conserved site
Domain	IPR000922	D-galactoside/L-rhamnose binding SUEL lectin domain
Domain	IPR001879	GPCR, family 2, extracellular hormone receptor domain
Domain	IPR003112	Olfactomedin-like domain
Domain	IPR003334	GPCR, family 2, latrophilin, C-terminal
Domain	IPR017981	GPCR, family 2-like, 7TM
Domain	IPR032471	GAIN domain, N-terminal
Family	IPR000832	GPCR, family 2, secretin-like
Family	IPR003924	GPCR, family 2, latrophilin
Homologous_superfamily	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily
Homologous_superfamily	IPR043159	D-galactoside/L-rhamnose binding SUEL lectin domain superfamily
Homologous_superfamily	IPR046338	GAIN domain superfamily

Domain Details Per Protein

Protein	Length	D-galactoside/L-rhamnose binding SUEL lectin domain	D-galactoside/L-rhamnose binding SUEL lectin domain superfamily	GAIN domain, N-terminal	GAIN domain superfamily	GPCR, family 2, extracellular hormone receptor domain	GPCR family 2, extracellular hormone receptor domain superfamily	GPCR, family 2, latrophilin	GPCR, family 2, latrophilin, C-terminal	GPCR, family 2-like, 7TM	GPCR, family 2, secretin-like	GPCR, family 2, secretin-like, conserved site	GPS motif	Olfactomedin-like domain
UniProtKB:A0A8M9QDE0 InterPro	1273
UniProtKB:F1QPV2 InterPro	1472
UniProtKB:A0A8M9QDD0 InterPro	1515
UniProtKB:A0A8M9QDD5 InterPro	1429
UniProtKB:A0A8M9QHX3 InterPro	1272
UniProtKB:A0A8M3B3W7 InterPro	1477
UniProtKB:A0A8M9Q7H9 InterPro	1217
UniProtKB:A0A8M3AXG2 InterPro	1464
UniProtKB:A0A8M3AXD8 InterPro	1496
UniProtKB:A0A2R8QN46 InterPro	1483
UniProtKB:A0A8M3B6R1 InterPro	1478
UniProtKB:A0A8M9Q7H1 InterPro	1458
UniProtKB:A0A8M9QLT9 InterPro	1279
UniProtKB:A0A8M9Q7H6 InterPro	1278
UniProtKB:A0A8M3BDJ0 InterPro	1434
UniProtKB:A0A8M9PV67 InterPro	1505
UniProtKB:A0A2R8QK81 InterPro	1416
UniProtKB:A0A8M9QHX6 InterPro	1445
UniProtKB:A0A8M9Q7G8 InterPro	1520
UniProtKB:A0A8M9QLU5 InterPro	1215
UniProtKB:A0A8M9QHW5 InterPro	1507
UniProtKB:A0A8M3AXE4 InterPro	1421
UniProtKB:A0A8M2BKM2 InterPro	1236
UniProtKB:A0A8M9QLT7 InterPro	1507

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	adgrl2a-201 (1) Ensembl	Ensembl	6,618 nt	Select Tool ZFIN BLAST
mRNA	adgrl2a-203 (1) Ensembl	Ensembl	6,643 nt	Select Tool ZFIN BLAST
mRNA	adgrl2a-204 (1) Ensembl	Ensembl	6,823 nt	Select Tool ZFIN BLAST
mRNA	adgrl2a-205 (1) Ensembl	Ensembl	6,651 nt	Select Tool ZFIN BLAST
mRNA	adgrl2a-206 (1) Ensembl	Ensembl	6,374 nt	Select Tool ZFIN BLAST
ncRNA	adgrl2a-002 (1) Ensembl	Ensembl	574 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations