Gene
slc40a1
- ID
- ZDB-GENE-000511-8
- Name
- solute carrier family 40 member 1
- Symbol
- slc40a1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Enables iron ion transmembrane transporter activity. Acts upstream of or within several processes, including hemoglobin biosynthetic process; hemopoiesis; and response to copper ion. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in digestive system; gill; nervous system; solid lens vesicle; and yolk syncytial layer. Used to study iron deficiency anemia. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu1041 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hemochromatosis type 4 | Alliance | Hemochromatosis, type 4 | 606069 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| iron deficiency anemia | slc40a1tp85c/tp85c | standard conditions | Bo et al., 2016 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ferroportin-1 | MFS transporter superfamily |
|---|---|---|---|
|
UniProtKB:Q9I9R3
|
562 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | ottdart00000003995 (1) | Havana | 3,749 nt | ||
| mRNA | ottdart00000004045 (1) | Havana | 2,763 nt | ||
| mRNA |
slc40a1-201
(1)
|
Ensembl | 3,780 nt |
Interactions and Pathways
No data available
Plasmids
No data available