Gene
pbx1a
- ID
- ZDB-GENE-000405-1
- Name
- pre-B-cell leukemia homeobox 1a
- Symbol
- pbx1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in hemopoiesis; swim bladder morphogenesis; and vasculature development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma. Is expressed in several structures, including central nervous system; head; pleuroperitoneal region; presumptive swim bladder; and swim bladder bud. Orthologous to human PBX1 (PBX homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu391 (9 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay | Alliance | Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay | 617641 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | KN homeodomain | PBX, PBC domain | Three Amino acid Loop Extension (TALE) homeobox |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9I9B7
|
428 | ||||||
|
UniProtKB:A0A8M6Z2J2
|
425 | ||||||
|
UniProtKB:Q9I9B6
|
346 |
Interactions and Pathways
No data available
Plasmids
No data available