Gene

notch3

ID

ZDB-GENE-000329-5

Name

notch receptor 3

Symbol

notch3 Nomenclature History

Previous Names

notch5
fa14b08
wu:fa14b08

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to have Notch binding activity. Involved in several processes, including animal organ development; blood vessel development; and neurogenesis. Predicted to localize to integral component of membrane; nucleus; and plasma membrane. Is expressed in several structures, including digestive system; mesoderm; nervous system; pronephros; and vasculature. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Orthologous to human NOTCH3 (notch receptor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

112 figures from 93 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 22 figures from 8 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With notch3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy 1	125310
		Lateral meningocele syndrome	130720
		?Myofibromatosis, infantile 2	615293

Associated With notch3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR000800	Notch domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR010660	Notch, NOD domain
Domain	IPR011656	Notch, NODP domain
Domain	IPR024600	Notch, C-terminal
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR008297	Notch
Family	IPR022331	Neurogenic locus Notch 3
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR035993	Notch-like domain superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like, conserved site	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Growth factor receptor cysteine-rich domain superfamily	Neurogenic locus Notch 3	Notch	NOTCH1 EGF-like calcium-binding domain	Notch, C-terminal	Notch domain	Notch-like domain superfamily	Notch, NOD domain	Notch, NODP domain
UniProtKB:Q800E4 InterPro	2468

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	notch3-201 (1) Ensembl	Havana	7921 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	notch3-202 (1) Ensembl	Ensembl	11630 nt	Select Tool ZFIN BLAST
mRNA	notch3-203 (1) Ensembl	Ensembl	2521 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations