Gene
micu1
- ID
- ZDB-GENE-070410-22
- Name
- mitochondrial calcium uptake 1
- Symbol
- micu1 Nomenclature History
- Previous Names
-
- zgc:162148 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity. Predicted to be involved in calcium ion import; mitochondrial calcium ion transmembrane transport; and positive regulation of mitochondrial calcium ion concentration. Predicted to localize to integral component of mitochondrial membrane; mitochondrial intermembrane space; and uniplex complex. Human ortholog(s) of this gene implicated in myopathy with extrapyramidal signs. Is expressed in female organism; heart; and heart tube. Orthologous to human MICU1 (mitochondrial calcium uptake 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Soman et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| myopathy with extrapyramidal signs | Alliance | Myopathy with extrapyramidal signs | 615673 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calcium uptake protein 1/2/3 | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair |
|---|---|---|---|---|---|
|
UniProtKB:E9QGA3
|
485 | ||||
|
UniProtKB:A0A8M3B503
|
487 | ||||
|
UniProtKB:A0A8M2B2M2
|
491 | ||||
|
UniProtKB:A4IG32
|
489 |
Interactions and Pathways
No data available
Plasmids