Kizil et al., 2018 - Is Alzheimer's Also a Stem Cell Disease? - The Zebrafish Perspective. Frontiers in cell and developmental biology   6:159 Full text @ Front Cell Dev Biol

FIGURE 1

A simplified comparison of the effects of Alzheimer’s disease on neural stem cell plasticity in mouse and zebrafish. In mouse, Amyloid deposition initiates pro-inflammatory response that potentiates Amyloid toxicity that impairs neural stem cell proliferation, neurogenesis, neuronal maturation, and synaptic integrity. This chronic inflammation suppresses anti-inflammatory factor Interleukin-4, which is beneficial for neuronal survival and synaptic integrity. In zebrafish, although Amyloid deposition follows a toxicity cascade similar to that of the mouse (activation of pro-inflammatory response and hampered synaptic integrity), Amyloid also leads to induction of anti-inflammatory factor Interleukin-4, which enhances neural stem cell proliferation, neurogenesis, and neuronal maturation. The effects of Interleukin-4 counteracts synaptic degeneration and reduced neural stem cell plasticity.

Acknowledgments:
ZFIN wishes to thank the journal Frontiers in cell and developmental biology for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Front Cell Dev Biol