FIGURE SUMMARY
Title

EGF receptor kinase suppresses ciliogenesis through activation of USP8 deubiquitinase

Authors
Kasahara, K., Aoki, H., Kiyono, T., Wang, S., Kagiwada, H., Yuge, M., Tanaka, T., Nishimura, Y., Mizoguchi, A., Goshima, N., Inagaki, M.
Source
Full text @ Nat. Commun.
Fig. 3

usp8 knockout zebrafish displays ciliopathy-related phenotypes. a Wild-type (WT) and usp8-knockout (usp8-KO) zebrafish with cystic kidney (arrows), hydrocephalus (arrowhead), and microphthalmia (white arrows) at 5 dpf. Scale bar, 500 μm. b Incidence of cystic kidney in WT (n = 75) and usp8 KO (n = 101) at 4 or 5 dpf. c–e Immunofluorescence analysis of cilia of pronephric duct of WT and usp8-KO at 27 hpf (c, sagittal plane) and at 4 dpf (d, transverse plane). Green, acetylated-tubulin; red, actin; blue: nuclei. Scale bars, 10 μm. Pronephric duct lumen diameter of WT (n = 11) and usp8 KO (n = 7) at 4 dpf are shown as mean ± SD in e. **p < 0.01, two-tailed unpaired student’s t-tests
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.
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