In vivo disease phenotypes. A, Representative examples of wild-type (top) and gnb5a/gnb5b mutant (bottom) zebrafish and relative enhancement of moving pixels. B, Representative qualitative analyses of normal (top) and arrhythmic (bottom) contraction profiles from wild-type and gnb5a/gnb5b mutant zebrafish treated with carbachol. C, Correlation of results obtained from manual (x axis) vs automatic (y axis) detection of beating frequency (top); distribution of normal (green) and arrhythmic (red) contraction patterns in baseline condition (B) and after treatment with carbachol (C) in wild-type and gnb5a/gnb5b mutant zebrafish (bottom). D, Representative echocardiograms of healthy (top) and cardiomyopathic (bottom) human individuals. Ventricles have been manually cropped, and the enhancement of moving pixels is overlaid. E, Representative qualitative analyses of normal (top) and poor (bottom) ventricular functions. F, Quantitative data collected from echocardiogram in 5 individuals. Each color represents 1 individual.
|Acknowledgments:||ZFIN wishes to thank the journal Circulation research for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Circ. Res.|