ZFIN ID: ZDB-EXP-230215-1
Experiment Conditions Description: chemical treatment by environment: topotecan
chemical treatment by environment: topotecan
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: topotecan
Synonyms: (4S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecin, topotecan, topotecane, topotecanum
Definition: A pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks.
Ontology: ChEBI [CHEBI:63632]  ( EBI )
Publication: Jing et al., 2020