ZFIN ID: ZDB-EXP-210324-6
Experiment Conditions Description: perforation: retina, chemical treatment by injection: DAPT, chemical treatment by injection: SB 431542
perforation: retina
Name: perforation
Synonyms:
Definition: Experimental condition in which a hole or break in the membranes of an organ or structure of the body is created.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000178]
Name: retina
Synonyms: retinas
Definition: Multi-tissue structure that contains the retinal neural layer and the retinal pigmented epithelium, and develops from the optic cup.
Ontology: Anatomy Ontology [ZFA:0000152]
chemical treatment by injection: DAPT
Name: chemical treatment by injection
Synonyms:
Definition: Chemical treatment in which the chemical is injected into the zebrafish.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000237]
Name: DAPT
Synonyms: gamma-secretase inhibitor IX, GSI-IX, tert-butyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)acetate, tert-butyl (2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]amino]-2-phenylacetate
Definition: A dipeptide consisting of alanylphenylglycine derivatised as a 3,5-difluorophenylacetamide at the amino terminal and a tert-butyl ester at the carboxy terminal. It is a gamma-secretase inhibitor.
Ontology: ChEBI [CHEBI:86193]  ( EBI )
chemical treatment by injection: SB 431542
Name: chemical treatment by injection
Synonyms:
Definition: Chemical treatment in which the chemical is injected into the zebrafish.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000237]
Name: SB 431542
Synonyms: 4-(4-(1,3-Benzodioxole-5-yl)-5-(2-pyridyl)-1H-imidazole-2-yl)benzamide, 4-[4-(2H-1,3-benzodioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl]benzamide, SB-431542, SB431542
Definition: A member of the class of benzamides that is 4-(imidazol-2-yl)benzamide carrying additional 1,3-benzodioxol-5-yl and pyridin-2-yl substituents at positions 4 and 5 respectively on the imidazole ring.
Ontology: ChEBI [CHEBI:91108]  ( EBI )
Publication: Sharma et al., 2020