ZFIN ID: ZDB-EXP-181228-3
Experiment Conditions Description: chemical treatment by environment: CFTRinh-172, chemical treatment by environment: afimoxifene
chemical treatment by environment: CFTRinh-172
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: CFTRinh-172
Synonyms: (inh)-172, 3-[(3-trifluoromethyl)phenyl]-5-[(3-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone, 4-({4-oxo-2-sulfanylidene-3-[3-(trifluoromethyl)phenyl]-1,3-thiazolidin-5-ylidene}methyl)benzoic acid, 5-[(4-carboxyphenyl)methylene]-2-thioxo-3-[(3-trifluoromethyl)phenyl]-4-thiazolidinone, C2992_SIGMA, CFTR(inh)-172, Cystic fibrosis transmembrane conductance regulator inhibitor CFTR(inh)-172, cystic fibrosis transmembrane regulator inhibitor 172
Definition: A thiazolidinone that is 2-thioxo-4-thiazolidinone which is substituted at position 3 by a (m--trifluoromethyl)phenyl group and at position 5 by a p-carboxybenzylidene group. It is an inhibitor of cystic fibrosis transmembrane conductance regulator, a membrane protein and chloride channel in vertebrates that is encoded by the CFTR gene.
Ontology: ChEBI [CHEBI:131686]  ( EBI )
chemical treatment by environment: afimoxifene
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: afimoxifene
Synonyms: 4-hydroxytamoxifen, 4-monohydroxytamoxifen, 4-OHT, afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Ontology: ChEBI [CHEBI:44616]  ( EBI )
Publication: Dasgupta et al., 2018