| ZFIN ID: ZDB-EXP-181004-3 |
Experiment Conditions Description: chemical treatment by environment: LY-310762 hydrochloride, chemical treatment by environment: fenfluramine
| chemical treatment by environment: LY-310762 hydrochloride |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | LY-310762 hydrochloride |
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| Synonyms: | 1-[2-(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-1-yl)ethyl]-4-(4-fluorobenzoyl)piperidinium chloride, 1-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-one hydrochloride, 1-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}-3,3-dimethyl-1,3-dihydro-2H-indol-2-one hydrochloride, LY-310,762 hydrochloride, LY-310762 HCl, LY-310762 hydrochloride, LY310762 HCl, LY310762 hydrochloride |
| Definition: | A hydrochloride resulting from the formal reation of equimolar amount of LY-310762 with hydrogen chloride. A potent and selective antagonist for the 5-hydroxytryptamine 1D (5-HT1D) receptor. |
| Ontology: | ChEBI [CHEBI:140935] ( EBI ) |
| chemical treatment by environment: fenfluramine |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | fenfluramine |
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| Synonyms: | (+-)-fenfluramine, 1-(m-trifluoromethyl-phenyl)-2-ethylaminopropane, 2-ethylamino-1-(3-trifluoromethylphenyl)propane, 3-(trifluoromethyl)-N-ethyl-alpha-methylphenethylamine, Ethyl-[1-methyl-2-(3-trifluoromethyl-phenyl)-ethyl]-amine, Fenfluramine, fenfluraminum, N-ethyl-1-(3-(trifluoromethyl)phenyl)propan-2-amine, N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine, N-ethyl-alpha-methyl-3-trifluoromethylphenethylamine |
| Definition: | A secondary amino compound that is 1-phenyl-propan-2-amine in which one of the meta-hydrogens is substituted by trifluoromethyl, and one of the hydrogens attached to the nitrogen is substituted by an ethyl group. It binds to the serotonin reuptake pump, causing inhbition of serotonin uptake and release of serotonin. The resulting increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior located in the hypothalamus. This suppresses the appetite for carbohydrates. Fenfluramine was used as the hydrochloride for treatment of diabetes and obesity. It was withdrawn worldwide after reports of heart valve disease and pulmonary hypertension. |
| Ontology: | ChEBI [CHEBI:5000] ( EBI ) |
| Publication: | Sourbron et al., 2017 |
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