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Gene

mfn2

ID
ZDB-GENE-081105-44
Name
mitofusin 2
Symbol
mfn2 Nomenclature History
Previous Names
  • mg:cb01g09
  • si:dkeyp-104h9.2
  • wu:fb79a11
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable GTPase activity. Acts upstream of or within several processes, including axonal transport of mitochondrion; axonogenesis; and neuromuscular junction development. Predicted to be located in mitochondrial outer membrane. Predicted to be integral component of membrane. Predicted to be intrinsic component of mitochondrial outer membrane. Is expressed in several structures, including heart; muscle; nervous system; otic vesicle; and ventral mesenchyme. Used to study Charcot-Marie-Tooth disease type 2. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; and Charcot-Marie-Tooth disease type 6. Orthologous to human MFN2 (mitofusin 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
4 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mfn2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease type 2A2A Alliance Charcot-Marie-Tooth disease, axonal, type 2A2A 609260
Charcot-Marie-Tooth disease type 2A2B Alliance Charcot-Marie-Tooth disease, axonal, type 2A2B 617087
Charcot-Marie-Tooth disease type 6 Alliance Hereditary motor and sensory neuropathy VIA 601152
Associated With mfn2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006884 Fzo/mitofusin HR2 domain
Domain IPR030381 Dynamin-type guanine nucleotide-binding (G) domain
Family IPR022812 Dynamin superfamily
Family IPR027089 Mitofusin-2
Family IPR027094 Mitofusin family
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length Dynamin superfamily Dynamin-type guanine nucleotide-binding (G) domain Fzo/mitofusin HR2 domain Mitofusin-2 Mitofusin family P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A8WIN6 757
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations