Gene

ikbkb

ID
ZDB-GENE-071115-2
Name
inhibitor of nuclear factor kappa B kinase subunit beta
Symbol
ikbkb Nomenclature History
Previous Names
  • ikk2 (1)
  • Ikkb (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Enables kinase activity. Acts upstream of or within regulation of cytokinesis and skin development. Predicted to be located in nucleus. Predicted to be part of IkappaB kinase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in breast cancer; combined immunodeficiency (multiple); dermatitis; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Anelli et al., 2009
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Shen et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ikbkb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 15A Alliance Immunodeficiency 15A 618204
immunodeficiency 15B Alliance Immunodeficiency 15B 615592
Associated With ikbkb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Domain IPR000626 Ubiquitin-like domain
Domain IPR000719 Protein kinase domain
Domain IPR041185 IKBKB, scaffold dimerization domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Domain Details Per Protein
Protein Length IKBKB, scaffold dimerization domain Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Ubiquitin-like domain Ubiquitin-like domain superfamily
UniProtKB:B0R199 779
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations