Gene

jak3

ID
ZDB-GENE-070725-4
Name
Janus kinase 3 (a protein tyrosine kinase, leukocyte)
Symbol
jak3 Nomenclature History
Previous Names
  • sb:eu418
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in T cell differentiation in thymus and natural killer cell differentiation. Predicted to localize to cytoskeleton and membrane. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia; adult T-cell leukemia; juvenile myelomonocytic leukemia; and megakaryocytic leukemia. Is expressed in thymus. Orthologous to human JAK3 (Janus kinase 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With jak3 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
janus kinase-3 deficiency Alliance SCID, autosomal recessive, T-negative/B-positive type 600802
Associated With jak3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000299 FERM domain
Domain IPR000719 Protein kinase domain
Domain IPR000980 SH2 domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR019749 Band 4.1 domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR041046 JAK, FERM F2 lobe domain
Domain IPR041155 FERM F1 lobe ubiquitin-like domain
Domain IPR041381 Jak1, pleckstrin homology-like domain
Family IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length Band 4.1 domain FERM domain FERM F1 lobe ubiquitin-like domain Jak1, pleckstrin homology-like domain JAK, FERM F2 lobe domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain SH2 domain SH2 domain superfamily Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, non-receptor Jak/Tyk2
UniProtKB:X1WHN6 1103
UniProtKB:B0V237 1103
UniProtKB:A0A2R8RWH2 1085
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations