Gene

sppl3

ID
ZDB-GENE-050913-71
Name
signal peptide peptidase 3
Symbol
sppl3 Nomenclature History
Previous Names
  • fb94d08
  • wu:fb94d08
  • zgc:114093
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Acts upstream of or within regulation of neuron apoptotic process. Predicted to be located in rough endoplasmic reticulum. Predicted to be active in Golgi-associated vesicle membrane. Predicted to be integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. Is expressed in central nervous system. Orthologous to human SPPL3 (signal peptide peptidase like 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sppl3 Human Ortholog
No data available
Associated With sppl3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR006639 Presenilin/signal peptide peptidase
Family IPR007369 Peptidase A22B, signal peptide peptidase
Domain Details Per Protein
Protein Length Peptidase A22B, signal peptide peptidase Presenilin/signal peptide peptidase
UniProtKB:F1RDS1 345
UniProtKB:Q5BP97 382
UniProtKB:Q4V8X9 345
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations