Gene

braf

ID
ZDB-GENE-040805-1
Name
B-Raf proto-oncogene, serine/threonine kinase
Symbol
braf Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to localize to cytosol and mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including LEOPARD syndrome 3; Noonan syndrome 7; astrocytoma (multiple); carcinoma (multiple); and cardiofaciocutaneous syndrome (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With braf Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cardiofaciocutaneous syndrome 1 Alliance Cardiofaciocutaneous syndrome 115150
colorectal cancer Alliance Colorectal cancer, somatic 114500
lung cancer Alliance Adenocarcinoma of lung, somatic 211980
lung cancer Alliance Nonsmall cell lung cancer, somatic 211980
Noonan syndrome 7 Alliance Noonan syndrome 7 613706
Noonan syndrome with multiple lentigines 3 Alliance LEOPARD syndrome 3 613707
Melanoma, malignant, somatic 155600
Associated With braf Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR003116 Raf-like Ras-binding
Domain IPR020454 Diacylglycerol/phorbol-ester binding
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Domain Details Per Protein
Protein Length Diacylglycerol/phorbol-ester binding Protein kinase, ATP binding site Protein kinase C-like, phorbol ester/diacylglycerol-binding domain Protein kinase domain Protein kinase-like domain superfamily Raf-like Ras-binding Serine/threonine-protein kinase, active site Serine-threonine/tyrosine-protein kinase, catalytic domain Ubiquitin-like domain superfamily
UniProtKB:Q5H8C3 358
UniProtKB:Q1LYG2 817
UniProtKB:Q761X4 575
UniProtKB:Q75V91 817
UniProtKB:Q75V92 777
UniProtKB:B3DFX5 777
UniProtKB:Q767H4 777
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations