Gene

cblb

ID
ZDB-GENE-030616-417
Name
Cbl proto-oncogene B, E3 ubiquitin protein ligase
Symbol
cblb Nomenclature History
Previous Names
  • si:busm1-25n23.1
  • si:busm1-39l02.2
  • si:dz25n23.1
  • si:dz39l02.2
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of epidermal growth factor-activated receptor activity and signal transduction. Predicted to act upstream of or within cell surface receptor signaling pathway and regulation of signaling. Predicted to be located in cytoplasm. Predicted to be active in membrane raft and plasma membrane. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Anelli et al., 2009
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cblb Human Ortholog
No data available
Associated With cblb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017907 Zinc finger, RING-type, conserved site
Domain IPR001841 Zinc finger, RING-type
Domain IPR003153 Adaptor protein Cbl, N-terminal helical
Domain IPR014741 Adaptor protein Cbl, EF hand-like
Domain IPR014742 Adaptor protein Cbl, SH2-like domain
Domain IPR015940 Ubiquitin-associated domain
Domain IPR024159 Adaptor protein Cbl, PTB domain
Domain IPR039520 E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass
Family IPR024162 Adaptor protein Cbl
Homologous_superfamily IPR011992 EF-hand domain pair
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR036537 Adaptor protein Cbl, N-terminal domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length Adaptor protein Cbl Adaptor protein Cbl, EF hand-like Adaptor protein Cbl, N-terminal domain superfamily Adaptor protein Cbl, N-terminal helical Adaptor protein Cbl, PTB domain Adaptor protein Cbl, SH2-like domain E3 ubiquitin-protein ligase CBL-B, RING finger, HC subclass EF-hand domain pair SH2 domain superfamily Ubiquitin-associated domain Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type Zinc finger, RING-type, conserved site
UniProtKB:F1Q742 939
UniProtKB:Q7ZZ86 461
UniProtKB:Q801W6 681
UniProtKB:F1Q5B6 926
UniProtKB:F1R6A7 934
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations