Gene

sptb

ID
ZDB-GENE-000906-1
Name
spectrin, beta, erythrocytic
Symbol
sptb Nomenclature History
Previous Names
  • b-spectrin (1)
  • fa09g12
  • riesling
  • ris
  • wu:fa09g12
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable actin binding activity and phospholipid binding activity. Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within embryonic hemopoiesis and erythrocyte development. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of spectrin. Is expressed in intermediate cell mass of mesoderm. Human ortholog(s) of this gene implicated in hereditary spherocytosis and hereditary spherocytosis type 2. Orthologous to human SPTB (spectrin beta, erythrocytic).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sptb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hereditary spherocytosis type 2 Alliance Spherocytosis, type 2 616649
Anemia, neonatal hemolytic, fatal or near-fatal 617948
Elliptocytosis-3 617948
Associated With sptb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001589 Actinin-type actin-binding domain, conserved site
Domain IPR001605 Pleckstrin homology domain, spectrin-type
Domain IPR001715 Calponin homology domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR041681 Pleckstrin homology domain 9
Family IPR016343 Spectrin, beta subunit
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR036872 CH domain superfamily
Repeat IPR002017 Spectrin repeat
Repeat IPR018159 Spectrin/alpha-actinin
Domain Details Per Protein
Protein Length Actinin-type actin-binding domain, conserved site Calponin homology domain CH domain superfamily PH-like domain superfamily Pleckstrin homology domain Pleckstrin homology domain 9 Pleckstrin homology domain, spectrin-type Spectrin/alpha-actinin Spectrin, beta subunit Spectrin repeat
UniProtKB:F1QQE5 2357
UniProtKB:B3DGY6 2357
UniProtKB:Q9DGM6 2357
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations