ZFIN ID: ZDB-PUB-991020-7
Differential expression of Tbx4 and Tbx5 in zebrafish fin buds
Tamura, K., Yonei-Tamura, S., and Belmonte, J.C.
Date: 1999
Source: Mechanisms of Development   87(1-2): 181-184 (Journal)
Registered Authors: Izpis├║a Belmonte, Juan Carlos
Keywords: T-box; Tbx4; Tbx5; zebrafish; gene expression; embryogenesis; fin bud
MeSH Terms:
  • Amino Acid Sequence
  • Animal Structures/metabolism*
  • Animals
  • Avian Proteins*
  • Eye/embryology
  • Gene Expression Regulation, Developmental*
  • In Situ Hybridization
  • Molecular Sequence Data
  • Phylogeny
  • Sequence Homology, Amino Acid
  • T-Box Domain Proteins/genetics
  • T-Box Domain Proteins/metabolism*
  • Time Factors
  • Zebrafish
  • Zebrafish Proteins*
PubMed: 10495283 Full text @ Mech. Dev.
In here we report the identification of two new members of the T-box gene family, zf-tbx5 and zf-tbx4, from the Zebrafish, Danio rerio. The amino acid sequences within the T-box domain share high homology with the mouse, chick, and newt orthologs. Whole mount in situ hybridization revealed specific expression of these genes in the eye and Fin buds. zf-tbx5 expression is restricted to the pectoral Fin bud, whilst zf-tbx4 transcripts are confined in the pelvic Fin bud. These results reveal the conserved expression pattern of Tbx5 and Tbx4 during appendage development in all animal species studied to date.