ZFIN ID: ZDB-PUB-990507-4
Patterning during organogenesis: genetic analysis of cardiac chamber formation
Yelon, D. and Stainier, D.Y.
Date: 1999
Source: Seminars in cell & developmental biology   10(2): 93-98 (Review)
Registered Authors: Stainier, Didier, Yelon, Deborah
Keywords: none
MeSH Terms:
  • Animals
  • Body Patterning/genetics*
  • Cell Lineage/genetics
  • Genes
  • Genetic Testing
  • Heart Atria/embryology*
  • Heart Ventricles/embryology*
  • Models, Biological
  • Mutation
  • Signal Transduction/genetics
  • Tretinoin/physiology
  • Zebrafish/embryology
PubMed: 10355033 Full text @ Sem. Cell Dev. Biol.
A classical genetic approach, in which mutagenized organisms are screened for phenotypes of interest, is appealing for the analysis of developmental processes. Here, we describe the advantages of zebrafish genetics for the study of heart development. As an example of the utility of this strategy, we discuss its potential to illuminate the molecular mechanisms of cardiac chamber formation. The signals that specify ventricular and atrial lineages and the differentiation pathways that produce distinct chambers are poorly understood. Recently identified zebrafish mutations that disrupt ventricular or atrial development promise to reveal genes essential for these processes.