|ZFIN ID: ZDB-PUB-990106-18|
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Isolation, expression and regulation of a zebrafish paraxis homologue
Shanmugalingam, S. and Wilson, S.W.
|Source:||Mechanisms of Development 78: 85-89 (Journal)|
|Registered Authors:||Shanmugalingam, Shantha, Wilson, Steve|
|Keywords:||somite; spadetail; cyclops; notail; one-eyed-pinhead|
|PubMed:||9858695 Full text @ Mech. Dev.|
Shanmugalingam, S. and Wilson, S.W. (1998) Isolation, expression and regulation of a zebrafish paraxis homologue. Mechanisms of Development. 78:85-89.
ABSTRACTThe formation of somites involves the subdivision of segmented presomitic mesoderm into segmentally arranged somite blocks. In mice and chicks, the basic-helix-loop-helix (bHLH) gene, paraxis, is involved in this process. Here, we report the isolation of a zebrafish homologue of paraxis, par1. par1 is expressed in presomitic paraxial mesoderm from late gastrula stages, and expression is maintained in ventrolateral cells after somite formation. In spt- embryos, par1 expression is both delayed and severely reduced whereas in flh- embryos, ectopic transcripts are detected in axial mesoderm. Spatial regulation of par1 expression within the somites is affected in several mutants with defects in axial midline tissues.