ZFIN ID: ZDB-PUB-980910-1
Vsx-2, a gene encoding a paired-type homeodomain, is expressed in the retina, hindbrain, and spinal cord during goldfish embryogenesis
Passini, M.A., Raymond, P.A., Schechter, N.
Date: 1998
Source: Dev. Brain Res.   109: 129-135 (Journal)
Registered Authors: Passini, Marco, Raymond, Pamela, Schechter, Nisson
Keywords: homeobox genes; ocular retardation; visual pathway; central nervous system; zebrafish; development
MeSH Terms:
  • Animals
  • Cell Differentiation
  • Gene Expression Regulation, Developmental/physiology*
  • Genes, Homeobox/genetics*
  • Goldfish/embryology
  • Goldfish/metabolism*
  • Humans
  • In Situ Hybridization
  • Retina/cytology
  • Retina/embryology*
  • Rhombencephalon/cytology
  • Rhombencephalon/embryology*
  • Spinal Cord/cytology
  • Spinal Cord/embryology*
PubMed: 9729330 Full text @ Dev. Brain Res.
Vsx-2 encodes a paired-type homeodomain and is the goldfish ortholog of the murine Chx10 gene. During development, Vsx-2 is expressed at high levels in goldfish and zebrafish retina. In addition to the retina, in situ hybridization studies using whole mount and cryosection embryos demonstrate that Vsx-2 is also expressed in subsets of neurons in the hindbrain and in the spinal cord. Expression begins approximately at the metencephalon-myelencephalon border and continues in a restricted lateral zone along the rostral-caudal axis of the spinal cord. These observations suggest a potential requirement for Vsx-2 in the specification and/or the maintenance of neurons in specific CNS regions during embryogenesis. Also discussed are other transcription factors which may act combinatorially with Vsx-2 to regulate neuronal differentiation.