|ZFIN ID: ZDB-PUB-980910-1|
Vsx-2, a gene encoding a paired-type homeodomain, is expressed in the retina, hindbrain, and spinal cord during goldfish embryogenesis
Passini, M.A., Raymond, P.A., Schechter, N.
|Source:||Dev. Brain Res. 109: 129-135 (Journal)|
|Registered Authors:||Passini, Marco, Raymond, Pamela, Schechter, Nisson|
|Keywords:||homeobox genes; ocular retardation; visual pathway; central nervous system; zebrafish; development|
|PubMed:||9729330 Full text @ Dev. Brain Res.|
Passini, M.A., Raymond, P.A., Schechter, N. (1998) Vsx-2, a gene encoding a paired-type homeodomain, is expressed in the retina, hindbrain, and spinal cord during goldfish embryogenesis. Dev. Brain Res.. 109:129-135.
ABSTRACTVsx-2 encodes a paired-type homeodomain and is the goldfish ortholog of the murine Chx10 gene. During development, Vsx-2 is expressed at high levels in goldfish and zebrafish retina. In addition to the retina, in situ hybridization studies using whole mount and cryosection embryos demonstrate that Vsx-2 is also expressed in subsets of neurons in the hindbrain and in the spinal cord. Expression begins approximately at the metencephalon-myelencephalon border and continues in a restricted lateral zone along the rostral-caudal axis of the spinal cord. These observations suggest a potential requirement for Vsx-2 in the specification and/or the maintenance of neurons in specific CNS regions during embryogenesis. Also discussed are other transcription factors which may act combinatorially with Vsx-2 to regulate neuronal differentiation.
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