PUBLICATION
Pax-2 in the chiasm
- Authors
- Alvarez-Bolado, G., M. Schwarz, and P. Gruss
- ID
- ZDB-PUB-971114-3
- Date
- 1997
- Source
- Cell and tissue research 290(2): 197-200 (Review)
- Registered Authors
- Gruss, Peter
- Keywords
- Pax-2; optic chiasm; axonal guidance; Sonic hedgehog; mutant mice; zebrafish
- MeSH Terms
-
- Animals
- Axonal Transport
- Axons/physiology*
- DNA-Binding Proteins/physiology*
- Humans
- Mice
- Nervous System Physiological Phenomena
- Optic Chiasm/physiology*
- PAX2 Transcription Factor
- Transcription Factors/physiology*
- PubMed
- 9321680 Full text @ Cell Tissue Res.
Citation
Alvarez-Bolado, G., M. Schwarz, and P. Gruss (1997) Pax-2 in the chiasm. Cell and tissue research. 290(2):197-200.
Abstract
Pax genes are expressed in specific patterns in the nervous system during development and in the adult. Recent findings suggest a link between the expression of Pax-2 and axonal guidance. Mice with a targeted deletion of Pax-2 are an excellent tool for studying axonal pathfinding at the molecular level, especially with respect to the optic chiasm. The date reviewed here suggest that Pax-2 regulates the expression of surface molecules involved in contact attraction and that the mutual regulation of the expression of Pax-2 and the Sonic hedgehog gene is of importance in the formation of the chiasm region.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping