PUBLICATION
Fish are like flies are like frogs: conservation of dorsal- ventral patterning mechanisms
- Authors
- Holley, S.A. and Ferguson, E.L.
- ID
- ZDB-PUB-970918-16
- Date
- 1997
- Source
- BioEssays : news and reviews in molecular, cellular and developmental biology 19(4): 281-284 (Review)
- Registered Authors
- Holley, Scott
- Keywords
- none
- MeSH Terms
-
- Animals
- Bone Morphogenetic Protein 4
- Bone Morphogenetic Proteins/genetics
- Bone Morphogenetic Proteins/physiology
- Drosophila Proteins*
- Drosophila melanogaster/embryology*
- Drosophila melanogaster/genetics
- Embryo, Nonmammalian/physiology
- Embryo, Nonmammalian/ultrastructure
- Embryonic Induction/physiology
- Evolution, Molecular
- Gene Expression Regulation, Developmental*
- Genes
- Genes, Insect
- Genes, Regulator
- Insect Proteins/genetics
- Insect Proteins/physiology
- Morphogenesis/physiology*
- Xenopus Proteins
- Xenopus laevis/embryology*
- Xenopus laevis/genetics
- Zebrafish/embryology*
- Zebrafish/genetics
- Zebrafish Proteins
- PubMed
- 9136625 Full text @ Bioessays
Citation
Holley, S.A. and Ferguson, E.L. (1997) Fish are like flies are like frogs: conservation of dorsal- ventral patterning mechanisms. BioEssays : news and reviews in molecular, cellular and developmental biology. 19(4):281-284.
Abstract
Genetic analysis of Drosophila has shown that a morphogenetic gradient of the Transforming Growth Factor-beta family member dpp patterns the embryonic dorsal-ventral axis. Molecular and embryological evidence from Xenopus has strongly suggested a similar role for Bmp-4, the dpp homolog, in patterning the dorsal-ventral axis of chordates. A recent report has now identified mutations in two genes, dino and swirl, that disrupt dorsal-ventral patterning in the zebrafish Danio rerio. Characterization of these mutations parallels findings from Drosophila, thus establishing a genetic framework for the analysis of dorsal-ventral patterning in a vertebrate.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping