PUBLICATION

Axon tracts correlate with Netrin-1a expression in the zebrafish embryo

Authors
Lauderdale, J.D., Davis, N.M., and Kuwada, J.Y.
ID
ZDB-PUB-970917-7
Date
1997
Source
Molecular and cellular neurosciences   9(4): 293-313 (Journal)
Registered Authors
Kuwada, John, Lauderdale, James D.
Keywords
none
MeSH Terms
  • Amino Acid Sequence
  • Animals
  • Axons/physiology*
  • Cloning, Molecular
  • DNA, Complementary/genetics
  • Embryo, Nonmammalian/cytology
  • Embryo, Nonmammalian/metabolism
  • Molecular Sequence Data
  • Muscles/cytology
  • Muscles/embryology
  • Mutation
  • Nerve Growth Factors/genetics
  • Nerve Growth Factors/metabolism
  • Neural Pathways/embryology
  • Spinal Cord/embryology
  • Spinal Cord/ultrastructure
  • Tissue Distribution
  • Tumor Suppressor Proteins
  • Zebrafish/embryology*
  • Zebrafish/genetics
  • Zebrafish/metabolism
PubMed
9268507 Full text @ Mol. Cell Neurosci.
Abstract
Netrins are secreted molecules that can attract or repel growth cones from a variety of organisms. In order to clarify the extent and scope of the effects of netrins for guiding growth cones, we have analyzed netrin-1a within the relatively simple and well-characterized nervous system of zebrafish embryos. netrin-1a is expressed in dynamic patterns that suggest that it guides the growth cones of a wide variety of neurons. The spatiotemporal relationship of netrin-1a expression and extending growth cones further suggests that netrins may act to delineate specific pathways and stimulate axonal outgrowth in addition to attracting and repelling growth cones. Furthermore, aberrant outgrowth by commissural growth cones in the spinal cords of floating head mutants, in which netrin-1a expression is altered, is consistent with an in vivo, chemoattractive action of netrin-1a. These data suggest that netrins act on many growth cones and influence their behavior in a variety of ways.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes