PUBLICATION

Genetic analysis of axon guidance and mapping in the zebrafish

Authors
Karlstrom, R.O., Trowe, T., and Bonhoeffer, F.
ID
ZDB-PUB-970129-10
Date
1997
Source
Trends in neurosciences   20(1): 3-8 (Review)
Registered Authors
Bonhoeffer, Friedrich, Karlstrom, Rolf, Trowe, Torsten
Keywords
none
MeSH Terms
  • Animals
  • Axons/physiology*
  • Mutation/physiology
  • Nervous System/cytology
  • Nervous System/embryology*
  • Zebrafish/genetics*
PubMed
9004410 Full text @ Trends Neurosci.
Abstract
Systematic genetic screens have been powerful tools in identifying genes responsible for axon guidance in fruitflies and nematodes. This approach has now been extended to the study of axon guidance and the formation of topographic neuronal connections in the vertebrate brain. A systematic genetic screen was used to identify genes responsible for precise axon pathfinding and targeting in the retinotectal system of the zebrafish (Danio rerio). Over 30 genes were found that affect either: (1) retinal axon pathfinding to the contralateral tectal lobe; or (2) the topographic connection between the eye and the tectum. The zebrafish retinotectal mutants represent a new resource for the study of axon guidance in the vertebrate brain.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Errata and Notes