PUBLICATION
Growth cone guidance by floor plate cells in the spinal cord of zebrafish embryos
- Authors
- Bernhardt, R.R., Nguyen, N., and Kuwada, J.Y.
- ID
- ZDB-PUB-961014-97
- Date
- 1992
- Source
- Neuron 8: 869-882 (Journal)
- Registered Authors
- Bernhardt, Robert, Kuwada, John
- Keywords
- none
- MeSH Terms
-
- Animals
- Axons/ultrastructure
- Functional Laterality
- Lasers
- Microscopy, Electron
- Mutation
- Neurons/physiology
- Neurons/ultrastructure*
- Spinal Cord/cytology
- Spinal Cord/embryology*
- Spinal Cord/physiology
- Zebrafish/embryology*
- PubMed
- 1586486 Full text @ Neuron
Citation
Bernhardt, R.R., Nguyen, N., and Kuwada, J.Y. (1992) Growth cone guidance by floor plate cells in the spinal cord of zebrafish embryos. Neuron. 8:869-882.
Abstract
The spinal cord of early zebrafish embryos contains a small number of neuronal classes whose growth cones all follow stereotyped, cell-specific pathways to their targets. Two classes of spinal neurons make cell-specific turns at or near the ventral midline of the spinal cord, which is occupied by a single row of midline floor plate cells. We tested whether these cells guide the growth cones by examining embryos missing the midline floor plate cells due either to laser ablation of the cells or to a mutation (cyc-1). In these embryos the growth cones followed both normal and aberrant pathways once near the ventral midline. This suggests that normally the midline floor plate cells do provide guidance cues, but that these cues are not obligatory.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping