ZFIN ID: ZDB-PUB-961014-939
Zebrafish Radar: a new member of the TGF-ß superfamily defines dorsal regions of the neural plate and the embryonic retina
Rissi, M., Wittbrodt, J., Delot, E., Naegeli, M., and Rosa, F.M.
Date: 1995
Source: Mechanisms of Development   49(3): 223-34 (Journal)
Registered Authors: Delot, Emmanuele, Rosa, Frederic, Wittbrodt, Jochen
Keywords: none
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • Conserved Sequence
  • Molecular Sequence Data
  • Neural Crest/embryology*
  • Retina/embryology*
  • Sequence Alignment
  • Transforming Growth Factor beta/genetics*
  • Transforming Growth Factor beta/isolation & purification
  • Zebrafish/embryology*
PubMed: 7734395 Full text @ Mech. Dev.
Proper development of metazoan embryos requires cell to cell communications. In many instances, these communications involve diffusible molecules, particularly members of the Transforming Growth Factor beta superfamily. In an effort to identify new members of this superfamily involved in the control of early zebrafish embryogenesis, we have isolated a gene, Radar, which appears to be conserved throughout vertebrate evolution and defines a new subfamily within the superfamily. Its pattern of expression suggests that Radar plays a role in the dorso- ventral polarity of the neural plate, blood islands formation, blood cells differentiation, the establishment of retinal dorso-ventral polarity and/or proper axonal retinotectal projections. Radar expression in ntl homozygous mutants indicates that notochord and hypochord development are intimately linked.