Effect of 3,4-dichloroaniline on the early life stages of the zebrafish (Brachydanio rerio): results of a comparative laboratory study
- Nagel, R., Bresch, H., Caspers, N., Hansen, P.D., Markert, M., Munk-, R., Scholz, N., and ter-Hofte, B.B.
- Ecotoxicology and environmental safety 21: 157-164 (Journal)
- Registered Authors
- Nagel, Roland
- MeSH Terms
- Aniline Compounds/analysis
- Aniline Compounds/toxicity*
- Fertility/drug effects
- Hydrogen-Ion Concentration
- 2065628 Full text @ Ecotoxicol. Environ. Saf.
Nagel, R., Bresch, H., Caspers, N., Hansen, P.D., Markert, M., Munk-, R., Scholz, N., and ter-Hofte, B.B. (1991) Effect of 3,4-dichloroaniline on the early life stages of the zebrafish (Brachydanio rerio): results of a comparative laboratory study. Ecotoxicology and environmental safety. 21:157-164.
An early life-stage (ELS) test was conducted with the zebrafish and 3,4-dichloroaniline (3,4-DCA) in eight laboratories. Based on the results from all eight laboratories, an LOEC of 200 micrograms 3,4-dichloroaniline/liter applies for the early life stages of the zebrafish. Effects observed were reduction of the survival rate and malformations. If the 100 micrograms/liter concentration additionally tested by one laboratory is included in the assessment, an LOEC of 100 micrograms 3,4-DCA/liter is obtained for the survival rate and increase in length. The NOEC is 20 micrograms/liter. The present results of a comparative laboratory study with the zebrafish show that a 42-day ELS test can be conducted with this species of fish, and affords meaningful results.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes