ZFIN ID: ZDB-PUB-961014-7
Determination of primary motoneuron identity in developing zebrafish embryos
Eisen, J.S.
Date: 1991
Source: Science (New York, N.Y.) 252: 569-572 (Journal)
Registered Authors: Eisen, Judith S.
Keywords: none
MeSH Terms:
  • Animals
  • Axonal Transport
  • Axons/physiology
  • Embryo, Nonmammalian/physiology*
  • Interneurons/cytology
  • Interneurons/physiology
  • Motor Neurons/cytology
  • Motor Neurons/physiology
  • Motor Neurons/transplantation*
  • Spinal Cord/embryology*
  • Zebrafish
PubMed: 1708527 Full text @ Science
The developmental determination of primary motoneurons was investigated by transplanting identified motoneurons in embryonic zebrafish to new spinal cord positions. Some cells moved from the new positions in which they were placed back to their original positions, thus it was difficult to evaluate whether they were determined. Among cells that remained in their new positions, those transplanted about 1 hour before axogenesis developed axonal trajectories that were appropriate for their original soma positions, whereas those transplanted 2 to 3 hours before axogenesis developed morphologies appropriate for their new soma positions. These results suggest that motoneuronal identity is determined before axogenesis.