ZFIN ID: ZDB-PUB-961014-598
Target recognition in neurogenesis: formation of the Mauthner axon cap
Kimmel, C.B., Sessions, S.K., and Kimmel, R.J.
Date: 1979
Source: Proc. Natl. Acad. Sci. USA 76(9): 4691-4694 (Journal)
Registered Authors: Kimmel, Charles B., Kimmel, Reida J.
Keywords: none
MeSH Terms:
  • Ambystoma/embryology*
  • Animals
  • Axons/ultrastructure
  • Brain/embryology*
  • Embryonic Induction
  • Fishes/embryology*
  • Microscopy, Electron
PubMed: 291997 Full text @ Proc. Natl. Acad. Sci. USA
To learn whether presence of a specific neuron, the Mauthner (M) cell, is required for the organization, during embryogenesis, of an associated synaptic neuropil, the M-axon cap, M-cell precursors were experimentally deleted in embryos of the zebra fish (Brachydanio rerio) and the axolotl (Ambystoma mexicanum). Examination of early larvae revealed that in about half of the cases M-axon caps were present in the absence of the corresponding M-cells. The locations and structures of such caps were approximately normal. We conclude that the M-cell is not a necessary target for normal development of the axon cap.