PUBLICATION
Early axonal contacts during development of an identified dendrite in the brain of the zebrafish
- Authors
- Kimmel, C.B., Hatta, K., and Metcalfe, W.K.
- ID
- ZDB-PUB-961014-581
- Date
- 1990
- Source
- Neuron 4: 535-545 (Journal)
- Registered Authors
- Hatta, Kohei, Kimmel, Charles B., Metcalfe, Walt
- Keywords
- none
- MeSH Terms
-
- Animals
- Lasers
- Trigeminal Nerve/ultrastructure
- Zebrafish/embryology*
- Synapses/ultrastructure*
- Rhombencephalon/embryology*
- Cyprinidae/embryology*
- Afferent Pathways/ultrastructure
- Axons/ultrastructure
- Dendrites/ultrastructure*
- Embryonic Induction
- PubMed
- 2322459 Full text @ Neuron
Citation
Kimmel, C.B., Hatta, K., and Metcalfe, W.K. (1990) Early axonal contacts during development of an identified dendrite in the brain of the zebrafish. Neuron. 4:535-545.
Abstract
We have identified the initial synaptic contacts made onto the Mauthner (M) cell, an identified neuron that arises during early development of the zebrafish hindbrain. The contacts are made by a small bundle of pioneering trigeminal sensory axons onto the M cell soma before it forms dendrites. The sensory bundle is then partially enveloped by the M cell. The lateral dendrite appears at about the site of the contact, and eventually the trigeminal inputs are shifted to its trunk. As the dendrite elongates, other sensory contacts are made on its distal regions, sequentially from the acoustico-vestibular nerve and the lateral line nerves. To learn whether the earliest inputs induce the initial outgrowth of the M cell dendrite, we ablated the trigeminal neurons by laser irradiation before they contacted the M cell. Morphogenesis of the M cell, including its dendrite, appeared normal.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping