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ZFIN ID: ZDB-PUB-961014-543
Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of ß-catenin
Kelly, G.M., Erezyilmaz, D.F., and Moon, R.T.
Date: 1995
Source: Mechanisms of Development   53(2): 261-273 (Journal)
Registered Authors: Kelly, Greg, Moon, Randall T.
Keywords: none
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cytoskeletal Proteins/biosynthesis*
  • Embryo, Nonmammalian/metabolism
  • Gene Expression Regulation, Developmental/physiology*
  • Molecular Sequence Data
  • Multigene Family
  • Phenotype
  • Protein Biosynthesis*
  • Proteins*
  • Trans-Activators*
  • Wnt Proteins
  • Xenopus
  • Xenopus Proteins
  • Zebrafish
  • Zebrafish Proteins
  • beta Catenin
PubMed: 8562427 Full text @ Mech. Dev.
Formation of the vertebrate axis may involve a Wnt signaling cascade similar to the Drosophila wingless pathway. Zebrafish wnt8 is a candidate for involvement in axis specification insofar as it is expressed maternally and when overexpressed it can induce goosecoid, a transcription factor normally expressed in the embryonic shield. In this study we demonstrate that beta-catenin, a cadherin associated protein in the Wnt pathway, is expressed maternally in zebrafish and is widely distributed in the early embryo. Overexpressing beta-catenin in early zebrafish embryos induces goosecoid and ntl, ultimately leading to a duplication of a complete secondary axis. These data are consistent with the involvement of beta-catenin in a Wnt signaling pathway which is involved in mesoderm induction in zebrafish.