PUBLICATION
Effects of retinoic acid on the expression of retinoic acid receptors during zebrafish embryogenesis
- Authors
- Joore, J., VanderLans, G.B.L.J., Lanser, P.H., Vervaart, J.M.A., Zivkovic, D., Speksnijder, J.E., and Kruijer, W.
- ID
- ZDB-PUB-961014-516
- Date
- 1994
- Source
- Mechanisms of Development 46: 137-150 (Journal)
- Registered Authors
- Jongejan-Zivkovic, Dana, Joore, Jos, Kruijer, Wiebe, Speksnijder, Johanna E.
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Central Nervous System/embryology
- Central Nervous System/metabolism
- Embryo, Nonmammalian/drug effects
- Embryo, Nonmammalian/metabolism
- Eye/embryology
- Eye/metabolism
- Gene Expression Regulation, Developmental/drug effects*
- In Situ Hybridization
- Mesoderm/metabolism
- Mice
- Molecular Sequence Data
- Organ Specificity
- Receptors, Retinoic Acid/biosynthesis*
- Receptors, Retinoic Acid/genetics
- Sequence Homology, Nucleic Acid
- Tissue Distribution
- Tretinoin/pharmacology*
- Zebrafish/embryology*
- Zebrafish/genetics
- PubMed
- 7918098 Full text @ Mech. Dev.
Citation
Joore, J., VanderLans, G.B.L.J., Lanser, P.H., Vervaart, J.M.A., Zivkovic, D., Speksnijder, J.E., and Kruijer, W. (1994) Effects of retinoic acid on the expression of retinoic acid receptors during zebrafish embryogenesis. Mechanisms of Development. 46:137-150.
Abstract
The cDNAs encoding the zebrafish homologs of retinoic acid receptor alpha(zRAR alpha) and gamma (zRAR gamma) were isolated and their expression studied in normal and retinoic acid (RA) treated embryos. Expression boundaries in the central nervous system are clearly different from those observed in the mouse, which can only partly be explained by morphogenetic differences. Treatment of embryos with RA induces ectopic zRAR gamma expression in anterior brain structures and both zRAR alpha and zRAR gamma expression in the eyes. Furthermore, striking differences occur in the zRAR gamma expression pattern in pharyngeal arch mesenchyme. Since the development of all of these structures has been shown to be affected by exogenous RA, our data suggest a role for zRAR alpha and zRAR gamma in the establishment of the RA phenotype in zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping