PUBLICATION
Conservation of engrailed-like homeobox sequences during vertebrate evolution
- Authors
- Holland, P.W. and Williams, N.A.
- ID
- ZDB-PUB-961014-465
- Date
- 1990
- Source
- FEBS letters 277: 250-252 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Evolution
- Fishes/genetics
- Genes, Homeobox*
- Mice/genetics
- Molecular Sequence Data
- Oligonucleotides/chemistry
- Polymerase Chain Reaction
- Xenopus laevis/genetics
- PubMed
- 1980115 Full text @ FEBS Lett.
Citation
Holland, P.W. and Williams, N.A. (1990) Conservation of engrailed-like homeobox sequences during vertebrate evolution. FEBS letters. 277:250-252.
Abstract
The Drosophila melanogaster developmental gene engrailed (en) is a member of a distinct subfamily of homeobox genes with a wide phylogenetic distribution. Here we report the use of reduced stringency polymerase chain reaction (PCR) to amplify and clone 8 genes related to en from 5 vertebrate species, including representatives of the most ancient vertebrate lineages. Nucleotide and deduced amino acid sequence comparisons between mouse, toad, zebrafish, lamprey and hagfish genes reveal extensive evolutionary conservation, and suggests that 2 en-like genes have been retained in most vertebrate lineages.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping