PUBLICATION
Midline structures and central nervous system coordinates in zebrafish
- Authors
- Hatta, K. and Kimmel, C.B.
- ID
- ZDB-PUB-961014-419
- Date
- 1993
- Source
- Perspectives on developmental neurobiology 1: 257-268 (Review)
- Registered Authors
- Hatta, Kohei, Kimmel, Charles B.
- Keywords
- none
- MeSH Terms
-
- Animals
- Central Nervous System/abnormalities
- Central Nervous System/embryology*
- Germ Layers/ultrastructure
- Embryonic and Fetal Development
- Mutation
- Morphogenesis
- Genes, Homeobox
- Embryonic Induction
- Nerve Tissue Proteins/genetics
- Nerve Tissue Proteins/physiology
- Embryo, Nonmammalian/abnormalities
- Embryo, Nonmammalian/physiology
- Embryo, Nonmammalian/ultrastructure
- Axons/physiology
- Notochord/embryology
- Zebrafish/embryology*
- Zebrafish/genetics
- Signal Transduction
- Homeodomain Proteins*
- Gene Expression Regulation
- PubMed
- 7916258
Citation
Hatta, K. and Kimmel, C.B. (1993) Midline structures and central nervous system coordinates in zebrafish. Perspectives on developmental neurobiology. 1:257-268.
Abstract
The embryonic zebrafish provides a relatively simple and accessible experimental system for understanding the underlying Bauplan of a vertebrate central nervous system (CNS) and for uncovering interactions critical for patterning. We show that features of CNS organization in normal, mutant, and developmentally ventralized zebrafish embryos can be explained by a three-axis hypothesis: Specifications occur according to position relative to coordinates along the anterior-posterior, dorsal-ventral, and luminal-pial axes of the neural tube. Midline tissues may be responsible for directly establishing the dorsal-ventral coordinates, but may only be indirectly involved in patterning along the anterior- posterior axis.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping