PUBLICATION
Toxicity of lindane, atrazine, and deltamethrin to early life stages of zebrafish (Brachydanio rerio)
- Authors
- Gorge, G. and Nagel, R.
- ID
- ZDB-PUB-961014-365
- Date
- 1990
- Source
- Ecotoxicology and environmental safety 20: 246-255 (Journal)
- Registered Authors
- Nagel, Roland
- Keywords
- none
- MeSH Terms
-
- Abnormalities, Drug-Induced
- Animals
- Atrazine/toxicity*
- Eggs
- Embryo, Nonmammalian/drug effects*
- Hexachlorocyclohexane/toxicity*
- Insecticides/toxicity*
- Nitriles
- Oxygen Consumption
- Pyrethrins/toxicity*
- Zebrafish
- PubMed
- 1708710 Full text @ Ecotoxicol. Environ. Saf.
Citation
Gorge, G. and Nagel, R. (1990) Toxicity of lindane, atrazine, and deltamethrin to early life stages of zebrafish (Brachydanio rerio). Ecotoxicology and environmental safety. 20:246-255.
Abstract
Fertilized eggs of zebrafish were exposed under flow- through conditions to several concentrations of the following pesticides: lindane 40, 80, 110, 130, and 150 micrograms/liter; atrazine 300, 1300, and 9100 micrograms/liter; deltamethrin 0.5, 0.8, and 1.2 micrograms/liter. Hatching, abnormalities in development (external deformations, edema, etc.), and mortality were recorded over a period of 35 days. At the end of the experiment, the body lengths of the fish were measured. Survival of juvenile fish after 35 days was reduced by increasing concentrations of all xenobiotics tested: lindane enhanced the mortality from 110 micrograms/liter and atrazine from 1300 micrograms/liter, and deltamethrin showed an effect even at the lowest test concentration (0.5 micrograms/liter). Other parameters were affected differently: hatching rate was reduced only by deltamethrin (from 0.8 micrograms/liter): lindane caused a decrease in growth (40 micrograms/liter) but had no effect on the other parameters. Atrazine increased the number of deformations and edema (1300 micrograms/liter) but did not influence hatching rate and growth. The sensitivity of the early life stages to the pesticides was compared with acute toxicity data (LC50) of adult zebrafish. The early life stages were less sensitive to lindane (118 versus 75 micrograms/liter), whereas in the case of atrazine (1300 versus 37,000 micrograms/liter) and deltamethrin (0.5 versus 2 micrograms/liter; 0.5 micrograms/liter was the lowest concentration tested) larvae were more sensitive.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping