ZFIN ID: ZDB-PUB-961014-292
Toxicity of complex chemical mixtures: acute and long-term effects on different life states of zebrafish (Brachydanio rerio)
Ensenbach, U. and Nagel, R.
Date: 1995
Source: Ecotoxicology and environmental safety   30: 151-157 (Journal)
Registered Authors: Nagel, Roland
Keywords: none
MeSH Terms:
  • Aniline Compounds/toxicity*
  • Animals
  • Behavior, Animal/drug effects
  • Dose-Response Relationship, Drug
  • Fresh Water
  • Hexachlorocyclohexane/toxicity*
  • Lethal Dose 50
  • Survival Rate
  • Time Factors
  • Water Pollutants, Chemical/toxicity*
  • Zebrafish/abnormalities
  • Zebrafish/growth & development*
  • Zebrafish/physiology
PubMed: 7539369 Full text @ Ecotoxicol. Environ. Saf.
Acute and long-term toxicity of 3,4-dichloroaniline and lindane to zebrafish were examined in tap water and water from the Rhine River and the toxicity of the binary mixture 3,4- dichloroaniline/lindane in tap water was investigated. The acute toxicity of 3,4-dichloroaniline and lindane was not influenced by the complex matrix of river water compared with tap water. The binary mixture of 3,4-dichloroaniline and lindane demonstrated an additive effect in the acute test. The survival rate of early life stages in river water was reduced by lindane (80 micrograms/liter), whereas the effects of 3,4- dichloroaniline on survival and growth were visible but not significant. The binary mixture of 2 micrograms/liter, 3,4- dichloroaniline and 40 micrograms/liter lindane in tap water had an influence on growth on the early life stages of zebrafish.