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ZFIN ID: ZDB-PUB-961014-1264
A pioneering growth cone in the embryonic zebrafish brain
Wilson, S.W. and Easter, S.S. Jr.
Date: 1991
Source: Proceedings of the National Academy of Sciences of the United States of America   88(6): 2293-2296 (Journal)
Registered Authors: Easter, Stephen S., Jr., Wilson, Steve
Keywords: none
MeSH Terms:
  • Animals
  • Axons/ultrastructure*
  • Brain/cytology
  • Brain/embryology*
  • Brain/ultrastructure
  • Embryo, Nonmammalian
  • Neurons/ultrastructure*
  • Zebrafish/embryology*
PubMed: 2006169 Full text @ Proc. Natl. Acad. Sci. USA
During development of the nervous system, growth cones navigate very precisely to their appropriate, often distant, targets. In insects, the task of establishing the earliest pathways is accomplished by a small number of neurons, termed pioneers. These neurons have axons that lay down an early scaffold, which provides a substrate for many later-developing axons. Here we show that a similar type of cell exists in the embryonic vertebrate brain. Using light- and electron-microscopic techniques we have examined the formation of one of the earliest tracts in the zebrafish brain. We find that it is pioneered at a precise time by the growth cone of a single neuron present in a predictable location. These observations show a fundamental similarity in the establishment of axonal pathways in the central nervous systems of both invertebrates and vertebrates.