| ZFIN ID: ZDB-PUB-961014-1203 |
The zebrafish Zf-Sox 19 protein: a novel member of the Sox family which reveals highly conserved motifs outside of the DNA-binding domain
Vriz, S. and Lovell-Badge, R.
| Date: | 1995 |
|---|---|
| Source: | Gene 153: 275-276 (Journal) |
| Registered Authors: | Vriz, Sophie |
| Keywords: | Cloning, nucleotide sequence, HMG box, Sry, development |
| MeSH Terms: |
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| PubMed: | 7875601 Full text @ Gene |
Citation
Vriz, S. and Lovell-Badge, R. (1995) The zebrafish Zf-Sox 19 protein: a novel member of the Sox family which reveals highly conserved motifs outside of the DNA-binding domain. Gene. 153:275-276.
ABSTRACT
A cDNA encoding a zebrafish Sox protein (Sry-type high- mobility-group box) was isolated and sequenced. The sequence within the HMG box is close to those of the B subfamily comprising mouse Sox-1, Sox-2, Sox-3 and Sox-14. While much of the rest of the zebrafish protein is unique, there are blocks of amino acids showing considerable identity with regions of Sox-1, -2 and -3. These domains may represent conserved parts of the protein, required for interaction with other proteins, and strengthen the assignment of the zebrafish gene, termed Zf-sox 19, to the B subfamily.
ADDITIONAL INFORMATION
- Genes / Markers (1)