ZFIN ID: ZDB-PUB-961014-1203
The zebrafish Zf-Sox 19 protein: a novel member of the Sox family which reveals highly conserved motifs outside of the DNA-binding domain
Vriz, S. and Lovell-Badge, R.
Date: 1995
Source: Gene   153: 275-276 (Journal)
Registered Authors: Vriz, Sophie
Keywords: Cloning, nucleotide sequence, HMG box, Sry, development
MeSH Terms:
  • Amino Acid Sequence
  • Animals
  • Cloning, Molecular
  • Conserved Sequence/genetics
  • DNA, Complementary/genetics
  • DNA-Binding Proteins/chemistry
  • DNA-Binding Proteins/genetics*
  • High Mobility Group Proteins/chemistry
  • High Mobility Group Proteins/genetics*
  • Molecular Sequence Data
  • SOX Transcription Factors
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Zebrafish/genetics*
  • Zebrafish Proteins*
PubMed: 7875601 Full text @ Gene
A cDNA encoding a zebrafish Sox protein (Sry-type high- mobility-group box) was isolated and sequenced. The sequence within the HMG box is close to those of the B subfamily comprising mouse Sox-1, Sox-2, Sox-3 and Sox-14. While much of the rest of the zebrafish protein is unique, there are blocks of amino acids showing considerable identity with regions of Sox-1, -2 and -3. These domains may represent conserved parts of the protein, required for interaction with other proteins, and strengthen the assignment of the zebrafish gene, termed Zf-sox 19, to the B subfamily.