PUBLICATION
The zebrafish Zf-Sox 19 protein: a novel member of the Sox family which reveals highly conserved motifs outside of the DNA-binding domain
- Authors
- Vriz, S. and Lovell-Badge, R.
- ID
- ZDB-PUB-961014-1203
- Date
- 1995
- Source
- Gene 153: 275-276 (Journal)
- Registered Authors
- Vriz, Sophie
- Keywords
- Cloning, nucleotide sequence, HMG box, Sry, development
- MeSH Terms
-
- Sequence Homology, Amino Acid
- Molecular Sequence Data
- Cloning, Molecular
- Sequence Analysis, DNA
- Amino Acid Sequence
- DNA-Binding Proteins/chemistry
- DNA-Binding Proteins/genetics*
- High Mobility Group Proteins/chemistry
- High Mobility Group Proteins/genetics*
- Zebrafish/genetics*
- SOX Transcription Factors
- DNA, Complementary/genetics
- Animals
- Zebrafish Proteins*
- Conserved Sequence/genetics
- PubMed
- 7875601 Full text @ Gene
Citation
Vriz, S. and Lovell-Badge, R. (1995) The zebrafish Zf-Sox 19 protein: a novel member of the Sox family which reveals highly conserved motifs outside of the DNA-binding domain. Gene. 153:275-276.
Abstract
A cDNA encoding a zebrafish Sox protein (Sry-type high- mobility-group box) was isolated and sequenced. The sequence within the HMG box is close to those of the B subfamily comprising mouse Sox-1, Sox-2, Sox-3 and Sox-14. While much of the rest of the zebrafish protein is unique, there are blocks of amino acids showing considerable identity with regions of Sox-1, -2 and -3. These domains may represent conserved parts of the protein, required for interaction with other proteins, and strengthen the assignment of the zebrafish gene, termed Zf-sox 19, to the B subfamily.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping