ZFIN ID: ZDB-PUB-961014-1111
A homeobox gene essential for zebrafish notochord development
Talbot, W.S., Trevarrow, B., Halpern, M.E., Melby, A.E., Farr, G., Postlethwait, J.H., Jowett, T., Kimmel, C.B., and Kimelman, D.
Date: 1995
Source: Nature 378: 150-157 (Journal)
Registered Authors: Halpern, Marnie E., Jowett, Trevor, Kimelman, David, Kimmel, Charles B., Melby, Bess, Postlethwait, John H., Talbot, William S., Trevarrow, Bill
Keywords: none
MeSH Terms: Amino Acid Sequence; Animals; Base Sequence; Cell Differentiation/genetics; Chromosome Mapping (all 27) expand
PubMed: 7477317 Full text @ Nature
The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.