PUBLICATION
A zebrafish NLRX1 isoform downregulates fish IFN responses by targeting the adaptor STING
- Authors
- Zhao, X., An, L.-.L., Gong, X.-.Y., Dan, C., Qu, Z.-.L., Sun, H.-.Y., Guo, W.-.H., Gui, J.-.F., Zhang, Y.-.B.
- ID
- ZDB-PUB-240110-13
- Date
- 2024
- Source
- Journal of virology 98(2): e0180123 (Journal)
- Registered Authors
- Gui, Jian-Fang, Zhang, Yi-Bing
- Keywords
- IFN antiviral response, NLRX1, negative regulation, protein degradation, transcript variant 4
- MeSH Terms
-
- Animals
- Immunity, Innate
- Interferons/metabolism
- Membrane Proteins*/metabolism
- Mitochondrial Proteins*/metabolism
- Protein Domains
- Protein Isoforms/genetics
- Ubiquitin-Protein Ligases
- Ubiquitination
- Zebrafish/immunology
- Zebrafish/metabolism
- Zebrafish Proteins*/metabolism
- PubMed
- 38193691 Full text @ J. Virol.
Citation
Zhao, X., An, L.-.L., Gong, X.-.Y., Dan, C., Qu, Z.-.L., Sun, H.-.Y., Guo, W.-.H., Gui, J.-.F., Zhang, Y.-.B. (2024) A zebrafish NLRX1 isoform downregulates fish IFN responses by targeting the adaptor STING. Journal of virology. 98(2):e0180123.
Abstract
In this study, we demonstrate that a transcript variant of zebrafish NLRX1, termed NLRX1-tv4, downregulates fish IFN response and promotes virus replication by targeting STING for protein degradation and impairing the interaction of STING and TBK1 and that its N- and C-terminus exhibit a similar inhibitory potential. Our results are helpful in clarifying the current contradictory understanding of structure and function of vertebrate NLRX1s.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping