PUBLICATION
Exploring the dynamic behavior of leukocytes with zebrafish
- Authors
- Michael, C., de Oliveira, S.
- ID
- ZDB-PUB-231114-11
- Date
- 2023
- Source
- Current opinion in cell biology 85: 102276102276 (Review)
- Registered Authors
- de Oliveira, Sofia
- Keywords
- Cell migration, Non-invasive imaging, Zebrafish
- MeSH Terms
-
- Animals
- Cell Movement/physiology
- Inflammation
- Leukocytes*/physiology
- Neutrophils
- Zebrafish*
- PubMed
- 37956533 Full text @ Curr. Opin. Cell Biol.
Citation
Michael, C., de Oliveira, S. (2023) Exploring the dynamic behavior of leukocytes with zebrafish. Current opinion in cell biology. 85:102276102276.
Abstract
Cell migration is a complex and intricate network of physical, chemical, and molecular events that ultimately leads to cell motility. This phenomenon is involved in both physiological and pathological processes such as proper immune and inflammatory responses. Dysregulation of cell migration machinery in immune cells can have a tremendous impact on the trajectory of inflammation, infection, and resolution. The small vertebrate, the zebrafish, has a remarkable capacity for genetic and pharmacological manipulation aligned to transparency that enables modulation and visualization of cell migration in vivo noninvasively. Such characteristics revolutionized the field of leukocyte biology, particularly neutrophils. In this review, we will focus on leukocyte migration and highlight findings made in the zebrafish that demonstrate how this small vertebrate system is a unique model to perform in vivo imaging and study mechanisms that regulate the dynamic behavior of immune cells in their native environment under homeostasis or upon challenge.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping