PUBLICATION
The Zebrafish for Preclinical Psilocybin Research
- Authors
- Syed, O., Tsang, B., Gerlai, R.
- ID
- ZDB-PUB-230910-68
- Date
- 2023
- Source
- Neuroscience and biobehavioral reviews 153: 105381 (Review)
- Registered Authors
- Gerlai, Robert T.
- Keywords
- affective disorders, anxiety, psilocybin, psychedelics, social behavior, zebrafish
- MeSH Terms
-
- Animals
- Anxiety
- Anxiety Disorders/drug therapy
- Hallucinogens*/pharmacology
- Hallucinogens*/therapeutic use
- Psilocybin*/pharmacology
- Psilocybin*/therapeutic use
- Zebrafish
- PubMed
- 37689090 Full text @ Neurosci. Biobehav. Rev.
Citation
Syed, O., Tsang, B., Gerlai, R. (2023) The Zebrafish for Preclinical Psilocybin Research. Neuroscience and biobehavioral reviews. 153:105381.
Abstract
In this review, we discuss the possible utility of zebrafish in research on psilocybin, a psychedelic drug whose recreational use as well as possible clinical application are gaining increasing interest. First, we review behavioral tests with zebrafish, focussing on anxiety and social behavior, which have particular relevance in the context of psilocybin research. Next, we briefly consider methods of genetic manipulations with which psilocybin's phenotypical effects and underlying mechanisms may be investigated in zebrafish. We briefly review the known mechanisms of psilocybin, and also discuss what we know about its safety and toxicity profile. Last, we discuss examples of how psilocybin may be employed for testing treatment efficacy in preclinical research for affective disorders in zebrafish. We conclude that zebrafish has a promising future in preclinical research on psychedelic drugs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping