PUBLICATION
Can we model autism using zebrafish?
- Authors
- Washbourne, P.
- ID
- ZDB-PUB-230826-47
- Date
- 2023
- Source
- Development, growth & differentiation 65(8): 453-458 (Review)
- Registered Authors
- Washbourne, Philip
- Keywords
- Autism Spectrum Disorders, Social Behavior, Zebrafish
- MeSH Terms
-
- Animals
- Autism Spectrum Disorder*/genetics
- Autism Spectrum Disorder*/metabolism
- Autism Spectrum Disorder*/psychology
- Autistic Disorder*/genetics
- Autistic Disorder*/metabolism
- Brain/metabolism
- Disease Models, Animal
- Humans
- Zebrafish/genetics
- PubMed
- 37623916 Full text @ Dev. Growth Diff.
Citation
Washbourne, P. (2023) Can we model autism using zebrafish?. Development, growth & differentiation. 65(8):453-458.
Abstract
Autism Spectrum Disorder (ASD) is one of the most common, heritable neuropsychiatric disorders in the world, affecting almost 1% of the population. The core symptoms used to diagnose ASD are decreased social interaction and increased repetitive behaviors. Despite the large number of affected individuals, the precise mechanisms that cause the disorder remain unclear. The identification of genes and environmental factors associated with ASD allows the study of the underlying mechanisms in animal models. Although ASD presents as a human disorder, based on recent advances in understanding their brain anatomy, physiology, behavior, and evolutionary conservation of neuronal cell types, I propose that zebrafish may provide novel insights into the etiology. This article is protected by copyright. All rights reserved.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping