PUBLICATION
Stepwise modulation of apical orientational cell adhesions for vertebrate neurulation
- Authors
- Zhang, L., Wei, X.
- ID
- ZDB-PUB-230804-36
- Date
- 2023
- Source
- Biological reviews of the Cambridge Philosophical Society 98(6): 2271-2283 (Journal)
- Registered Authors
- Wei, Xiangyun
- Keywords
- Claudins, Crumbs, Eph receptors, Ephrins, Na+/K+-ATPase, Occludin, adherens junction, cadherins, cell polarity, neurulation, orientational cell adhesion, tight junction, tubulogenesis
- MeSH Terms
-
- Animals
- Cell Adhesion
- Neural Plate/metabolism
- Neural Tube/metabolism
- Neurulation*
- Zebrafish*
- PubMed
- 37534608 Full text @ Biol. Rev. Camb. Philos. Soc.
Citation
Zhang, L., Wei, X. (2023) Stepwise modulation of apical orientational cell adhesions for vertebrate neurulation. Biological reviews of the Cambridge Philosophical Society. 98(6):2271-2283.
Abstract
Neurulation transforms the neuroectoderm into the neural tube. This transformation relies on reorganising the configurational relationships between the orientations of intrinsic polarities of neighbouring cells. These orientational intercellular relationships are established, maintained, and modulated by orientational cell adhesions (OCAs). Here, using zebrafish (Danio rerio) neurulation as a major model, we propose a new perspective on how OCAs contribute to the parallel, antiparallel, and opposing intercellular relationships that underlie the neural plate-keel-rod-tube transformation, a stepwise process of cell aggregation followed by cord hollowing. We also discuss how OCAs in neurulation may be regulated by various adhesion molecules, including cadherins, Eph/Ephrins, Claudins, Occludins, Crumbs, Na+ /K+ -ATPase, and integrins. By comparing neurulation among species, we reveal that antiparallel OCAs represent a conserved mechanism for the fusion of the neural tube. Throughout, we highlight some outstanding questions regarding OCAs in neurulation. Answers to these questions will help us understand better the mechanisms of tubulogenesis of many tissues.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping