PUBLICATION
Transcription Pattern of Neurotrophic Factors and Their Receptors in Adult Zebrafish Spinal Cord
- Authors
- Cacialli, P., Ricci, S., Lazzari, M., Milani, L., Franceschini, V.
- ID
- ZDB-PUB-230715-49
- Date
- 2023
- Source
- International Journal of Molecular Sciences 24(13): (Journal)
- Registered Authors
- Cacialli, Pietro
- Keywords
- aquatic animal model, neurotrophin, neurotrophin-receptor TRK, spinal cord, zebrafish
- MeSH Terms
-
- Animals
- Nerve Growth Factors*/metabolism
- RNA, Messenger/metabolism
- Receptor, trkA/genetics
- Receptors, Nerve Growth Factor/genetics
- Spinal Cord/metabolism
- Zebrafish*/genetics
- Zebrafish*/metabolism
- PubMed
- 37446129 Full text @ Int. J. Mol. Sci.
Citation
Cacialli, P., Ricci, S., Lazzari, M., Milani, L., Franceschini, V. (2023) Transcription Pattern of Neurotrophic Factors and Their Receptors in Adult Zebrafish Spinal Cord. International Journal of Molecular Sciences. 24(13):.
Abstract
In vertebrates, neurotrophins and their receptors play a fundamental role in the central and peripheral nervous systems. Several studies reported that each neurotrophin/receptor signalling pathway can perform various functions during axon development, neuronal growth, and plasticity. Previous investigations in some fish species have identified neurotrophins and their receptors in the spinal cord under physiological conditions and after injuries, highlighting their potential role during regeneration. In our study, for the first time, we used an excellent animal model, the zebrafish (Danio rerio), to compare the mRNA localization patterns of neurotrophins and receptors in the spinal cord. We quantified the levels of mRNA using qPCR, and identified the transcription pattern of each neurotrophin/receptor pathway via in situ hybridization. Our data show that ngf/trka are the most transcribed members in the adult zebrafish spinal cord.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping